The Center City Neighborhood of West Hollywood is the area south of Sunset Boulevard, between La Cienega and Fairfax, with Rosewood Ave to the south.

The Center City Neighborhood boasts several large, historic apartment buildings (such as La Fontaine, El Mirador and Villa Italia) dating back to the 1920s and 1930s. There is also a high concentration of condominiums, smaller apartment buildings, with some single-family homes and duplexes mixed in.

The Center City Neighborhood also has three parks; Kings Road Park, Laurel Park and Hart Park.